Negative Selection

Negative selection is the process during which immature T-cells are selected against if they bind strongly to self-epitoptes presented by thymic cells. Compared to positive selection, which selects for weak interactions, negative selection selects for no interactions. Otherwise, some interactions between T-cells and self-epitopes would result in autoimmunity. The distinguishing point is that positive selection shapes a T-cell's ability to bind to MHC, and negative selection shapes a T-cell's ability to bind a foreign (non-self) epitope.

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