Positive Selection

Positive selection is the process during which immature, double-positive T-cells are selected to survive based on their ability to bind to MHC molecules. T-cells that bind to MHC I or MHC II molecules weakly (not too strongly or too weakly) are selected to survive. It is during negative selection that T-cells are selected for their inability to bind to self epitopes.

An immature T-cell that binds weakly to an MHC I molecule acquires a CD8 receptor and eventually differentiates into a TCD8 lymphocyte. On the other hand, immature T-cell that binds weakly to an MHC II molecule acquires a CD4 receptor and eventually differentiates into a TCD4 lymphocyte.

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